PLLA-PEG Injectable Facial Filler Overview

Dermaxgel® PLLA-PEG Injectable Facial Filler is a milky white, sterile, biodegradable viscous gel implant. Utilizing a pre-filled syringe system, it combines instant filling with long-lasting effects to restore skin tissue volume through injection, achieving facial rejuvenation and aesthetic contouring.

1.Vial Details

Ingredients: Sodium Hyaluronate, PLLA-PEG Microspheres, Lidocaine Hydrochloride, BDDE Crosslinking Agent, Sodium Chloride, Injection Water Phosphate Buffer System.

Stability: 24-month shelf life through irradiation sterilization.

Specifications: 1 mL/syringe, 2 mL/syringe, 3 mL/syringe

Adjustable concentrations support versatile applications across cheeks, temples, forehead, and hands.

2.Structural Composition

Dermaxgel® PLLA-PEG Injectable Facial Filler is a composite gel system. Its primary components include: PLLA-PEG microspheres, active ingredients at a formulation concentration of 20.7%, responsible for long-term stimulation of collagen regeneration. Cross-linked sodium hyaluronate gel: suspension carrier, providing immediate filling support. Sodium hyaluronate is labeled at 16mg/mL, produced via microbial fermentation and crosslinked with BDDE. The gel carrier additionally contains 0.3% lidocaine hydrochloride to effectively reduce discomfort during injection and enhance treatment comfort. All components are sealed within a single-use, pre-filled syringe.

Mechanism of Action

Following injection, the PLLA-PEG facial filler is implanted into the deep dermis and superficial periosteum for physical augmentation. Immediate improvement in skin volume and contour is achieved through the action of sodium hyaluronate gel particles.

Dermaxgel® Injectable PLLA-PEG Composite Facial Filler achieves long-lasting collagen regeneration through a “guided regeneration” mechanism. Its action begins with a temporary scaffold formed by degradable PLLA-PEG microspheres and gel. Within weeks of implantation, the material initiates controlled degradation. This process is recognized by the body as a mild regenerative signal rather than an inflammatory response, precisely recruiting reparative macrophages and fibroblasts. Within the locally formed regenerative microenvironment, fibroblasts are activated and synthesize large quantities of Type I and Type III collagen. Newly synthesized collagen deposits spatially along the original scaffold, while the PLLA material fully degrades over subsequent months. This achieves a natural transition from “physical filling” to “biological regeneration,” enabling long-term, natural volume maintenance and rejuvenation effects through newly formed autologous collagen tissue. PLLA-PEG microspheres gradually degrade through ester bond hydrolysis into lactic acid, which is ultimately metabolized into carbon dioxide and water and excreted through natural physiological processes.

Long-lasting Maintenance

The PLLA-PEG microspheres contained in the product act as a biological scaffold, continuously promoting the regeneration of endogenous collagen. This extends and optimizes the filling effect, delivering natural, enduring tissue support and skin texture improvement.

1. Patient Suitability

Ideal for anti-aging seekers desiring firmness and contour enhancement.

Requires physician review for allergies, keloids, pregnancy, or breastfeeding.

Core Technology Edge

The hyaluronate carrier system ensures even microsphere distribution, exact dosing from pre-filled vials, and inflammation reduction via high biocompatibility. This innovation powers safer, more predictable PLLA-PEG injectable filler outcomes for clinical excellence.

B2B Factory Solutions

Collaborate with our Poly-L-Lactic Acid-Polyethylene Glycol facility for bulk PLLA-PEG microspheres production, custom formulations, and white-label packaging. Access competitive pricing, rapid scaling, and global supply chain support to dominate the facial implant filler market.

Additional Information

1.Indications

This product is indicated as a dermal filler for injection into the deep dermis, deep subcutaneous tissue, and superficial periosteum to correct facial depressions and contour laxity caused by tissue volume loss.

2.Sterilization Method

The gel in the pre-filled syringe is sterilized by high-temperature steam; the accompanying injection needles are sterilized by ethylene oxide. Usage Guidelines: This product is for single-use only.

3.Precautions

Strict adherence to sterile surgical procedures is mandatory during use. Refer to the enclosed instructions for detailed usage guidelines.