Ama-filler esikhumba aqukethe i-hyaluronic acid avule umnyango omusha emkhakheni wezokwelapha wobuhle emashumini eminyaka amabili edlule, enikeza isixazululo esiguquguqukayo nesihambisana nomzimba sokuvuselela ubuso, ukubuyisela ivolumu, nokulungisa imibimbi okukhanga iziguli eziningi emhlabeni jikelele. Lawa ama-gel angenziwa ngomjovo aqukethe i-hyaluronic acid, i-glycosaminoglycan eyenzeka ngokwemvelo emzimbeni womuntu edlala indima ebalulekile ekugcineni ukujiya kwesikhumba, ukuvumelana, nokwakheka komzimba ngokusebenzisa amandla ayo amangalisayo okubopha amanzi nokubamba iqhaza ekuxhumaneni kwe-extracellular matrix. Njengoba isidingo sezimiso zobuhle ezingadingi ukuhlinzwa siqhubeka nokukhula unyaka nonyaka, odokotela neziguli zombili zifuna ama-filler esikhumba aletha imiphumela ebonakalayo, ebukeka yemvelo ngokuncane kakhulu kwesikhathi sokuphumula kanye nephrofayili yokuphepha evumelanayo kuzo zonke izinkomba zokwelashwa ezahlukene. Phakathi kwezinketho eziningi ezitholakala emakethe namuhla, i-Dermaxgel ivele njengomkhiqizo ohlukile ohlangana nobuchwepheshe obuthuthukisiwe bokuxhumanisa kanye namazinga aphezulu kakhulu okuqondisa ukuhlangabezana nezidingo ezahlukene neziguquguqukayo zabachwepheshe bezobuhle ezindaweni zokwelapha nezamabhizinisi. Ukuze siqonde ngokugcwele ukuthi ama-filler e-Dermaxgel anikeza ini, kubalulekile ukuqonda ukuthi izici zawo zokwakheka njengobulukhuni be-gel, amandla okugcina amanzi, kanye nokuhlelwa kwe-microarchitectural kunquma kanjani ukuziphatha kwawo kwezomtholampilo nokufaneleka kwezindawo ezahlukene zokwelashwa kanye nezakhiwo zomzimba zeziguli. Lwazi oluyisisekelo lunika am

I-Dermaxgel inikeza izinhlobo ezimbili zemikhiqizo ethize—i-Dermaxgel Deep kanye ne-Dermaxgel Ultradeep—ngayinye yakhelwe ukujula okuthile komjovo kanye nenhloso yezokwelapha, kungaba ukukhulisa ivolumu yesifuba esimaphakathi, ukubumba izihlathi, ukulungisa imibotshana ejulile, noma ukusekela izakhiwo ezindaweni ezithintwa ukuncipha kwamathambo okubangelwa ukuguga. Ukuqonda amaphrofayili ezakhiwo zalezi zihlanganisi akuyona nje into yokufunda; kuthinta ngqo ukwenziwa kwezinqumo zezokwelapha, kuvumela abasebenzisi ukuthi bakhethe umkhiqizo ofanele kakhulu emzimbeni womuntu ngamunye, izinhloso zobuhle, kanye necebo lokwelapha ngokuzethemba nangokunemba. Ukubaluleka kwalo mkhuba owenziwe ngokukhethekile akukwazi ukugcizelelwa kakhulu, ngoba ukukhetha okungalungile kwe-filler kungaholela emiphumeleni engaphansi njengokulungisa ngokweqile, ukulungisa okunganele, ukubola kusenesikhathi, ukubukeka okungokwemvelo, noma ngisho nezingozi ezifana nokuhamba komkhiqizo noma ukungalingani kwezicubu. Ngakho-ke, ukuhlaziywa okuphelele kokuziphatha kokuvuvukala, izici ze-rheological, i-microstructure, kanye nokwakheka kwamakhemikhali kwe-Dermaxgel Deep kanye ne-Dermaxgel Ultradeep uma kuqhathaniswa nemikhiqizo ehamba phambili yabancintisana nayo kunikeza ukuqonda okubalulekile okungaphakamisa izinga lokunakekelwa emitholampilo yobuhle kulo lonke uhlelo lokusebenza. Lesi sihloko sihlose ukuletha ngqo lokho—ukuhlolwa okunemininingwane, okusekelwe ebufakazini kokuthi izihlanganisi ze-Dermaxgel zichazwa kanjani nokuthi izici zazo zezakhiwo ziguqulelwa kanjani ezuzweni olubonakalayo lwezokwelapha kubasebenzisi kanye neziguli ezifuna imiphumela ethembekile, emihle. Ekupheleni kwalokhu kuxoxisana, abafundi bazoba nenkambiso ecacile yokufanisa amaphrofayili ezakhiwo ze-filler nezinkomba zezokwelapha, ngaleyo ndlela kuthuthukiswe imiphumela futhi kuncishiswe isidingo sokulungisa okwengeziwe noma ukubuyekezwa.

Ukusebenza kwanoma yiluphi uhlobo lwe-hyaluronic acid dermal filler kunqunywa ngokuyisisekelo ubuchwepheshe bokuxhumanisa obusetshenziswa ngesikhathi sokukhiqizwa kwayo kanye nezinga eliqondile lokwakheka elilawula izici zayo zokugcina zomzimba namakhemikhali. Ukuxhumanisa kuhilela ukubopha amakhemikhali izintambo ze-hyaluronic acid ndawonye kusetshenziswa i-ejenti yokuxhumanisa—evame kakhulu i-1,4-butanediol diglycidyl ether (BDDE)—ukuze kwakheke inethiwekhi ye-gel enezinhlangothi ezintathu ezingamelana nokubola okusheshayo kwe-enzymatic futhi inikeze ukwesekwa okuhlala njalo komshini lapho ijovwa esikhunjeni isikhathi eside. Izinga lokuxhumanisa, ukusebenza kahle komzamo wokuxhumanisa, kanye nokuba khona kwanoma yikuphi ukuxhumanisa okusele konke kuthinta ubulukhuni be-filler, ukuhlanganisa, ukuphila isikhathi eside, kanye ne-biocompatibility ngezindlela ezingalinganiseka futhi ezibalulekile ngokomtholampilo. I-Dermaxgel isebenzisa inqubo yokuxhumanisa elungiselelwe kahle eyenza izinga eliphezulu lokuxhumanisa okufanayo, okuholela enethelini ye-gel enokwelula okuhle kakhulu kanye nezinsalela ezincane zamamonoma wamahhala ezingadala ukusabela okungalungile ezicini noma zilimaze ukuphepha komkhiqizo. Lokhu kunaka ukunemba kokuxhumanisa kungenye yezizathu zokuthi kungani izi-filler ze-Dermaxgel zibonisa izici ze-rheological ezihambisanayo kanye nemiphumela yomtholampilo ebonakalayo kuwo wonke ama-batch, zinikeza abasebenzisi ukuzethemba ekusebenzeni kwazo futhi zivumela imiphumela yokwelashwa ephindaphindekayo. Ngaphezu kwalokho, ukuzibophezela kwenkampani ekuqeqeqeni kubonakala ekugcineni kwayo izindinganiso zamazwe ngamazwe ezifana ne-ISO 13485 kanye ne-CE certification, okuyizimpawu zomkhiqizi wedivayisi yezokwelapha ovuthiwe futhi onesibopho ozinikele enhlalakahleni yesiguli.

Ngaphandle kokuxhumanisa, ukwakhiwa kwe-dermal filler kuhilela izinto eziningi ezengeziwe ezihlangene zakha isimo sayo esakhiwo, okubandakanya ukugxila kwe-hyaluronic acid, isisindo samachungechunge e-HA asetshenzisiwe, ukusatshalaliswa kosayizi wezinhlayiya uma kukhulunywa ngama-gel anezinhlayiya, kanye nohlelo lokubhafa olugcina i-pH yomzimba kanye ne-osmolarity ngaphakathi komkhiqizo womjovo. I-Dermaxgel Deep ne-Dermaxgel Ultradeep zakhiwe ngokugxila kwe-HA okulinganiswe ngokucophelela okulinganisa amandla okuphakamisa nokuhlanganiswa kwezicubu, kuqinisekisa ukuthi i-filler inikeza ukulungiswa kwevolumu ngokushesha ngenkathi isazwakala njengento yemvelo lapho uthinta futhi ihlanganiswa kahle ne-extracellular matrix ezungezile. Izakhiwo ze-rheological zalawa ma-filler—ikakhulukazi i-elastic modulus G', elinganisa ubulukhuni be-gel, kanye ne-viscous modulus G'', ebonisa ukudluliswa kwamandla—zilungiswa ngokuqondile ngokulungisa lezi zici zokwakheka ukuze zihambisane nezidingo zemishini zezindawo ezahlukene zomzimba namazinga omjovo. Ngokwesibonelo, i-filler ye-G' ephezulu ilungele imijovo ejulile ye-supraperiosteal lapho kudingeka khona amandla okuphakamisa aqinile, kanti i-filler ethambile, evumelana nezimo ingase ibe ngcono kumjovo we-dermal ongajulile noma izindawo ezibucayi njenge-tear trough noma indawo ye-perioral. Isu lokwakheka kwe-Dermaxgel liqinisekisa ukuthi zonke izinhlobonhlobo zomkhiqizo zihlala endaweni ethile, echazwe kahle ngaphakathi kwezwe le-rheological, livumela odokotela ukuthi benze izinqumo zomkhiqizo ezinolwazi, ezisekelwe emzimbeni ezihambisana nezimiso zemithi yobuhle enembayo. Leli zinga lobuchwepheshe bokwakheka libuye lisekele ukuphepha kweziguli ngokunciphisa ingozi yokusetshenziswa komkhiqizo okungalungile noma ukusetshenziswa okungaphandle komhlahlandlela okungaholela emiphumeleni engajabulisi noma imiphumela emibi.

Ukuze kuhloliswe ngendlela efanele izici zesakhiwo kanye nemisebenzi ye-Dermaxgel Deep ne-Dermaxgel Ultradeep kanye nemikhiqizo ebancintisana nayo, kusetshenziswe indlela yokuchaza izindlela eziningi eyayihlanganisa izilinganiso zesilinganiso sokuvuvukala, i-oscillatory rheology, i-scanning electron microscopy (SEM), kanye ne-Fourier-transform infrared spectroscopy (FTIR) endaweni elawulwayo yelabhorethri. Ngayinye yalezi zindlela inikeza ulwazi oluhambisanayo mayelana nezakhiwo zomzimba namakhemikhali ze-filler, idala isithombe esibanzi sendlela i-gel eziziphatha ngayo kokubili ngaphandle komzimba (in vitro) futhi, ngokunwetshwa, ngaphakathi komzimba (in vivo) ngemuva kokujova ezicini zobuso. Ukuhlolwa kwesilinganiso sokuvuvukala kulinganisa ikhono lenethiwekhi ye-gel ehlanganisiwe lokumunca nokugcina amanzi, okuyinkomba eqondile yamandla ayo okunisela kanye namandla ayo okuhlanganiswa nezicubu ezizungezile ngenkathi kunomthelela ekulungiseni ivolumu okuhlala njalo ngokuhamba kwesikhathi. Isilinganiso esiphakeme sokuvuvukala singaba usizo ezindlini zokunikeza ivolumu lapho ukubopha amanzi kunomthelela ekuqhubekeni kwevolumu, kodwa ukuvuvukala ngokweqile kungaholela ekubukeni okungokwemvelo "okugcwele kakhulu" noma ukwanda kwengozi yokuvuvukala ngemuva kokujova, okwenza kube ipharamitha ebalulekile ukuyiqapha kokubili ngesikhathi sokuthuthukiswa komkhiqizo kanye nokukhethwa komtholampilo. I-oscillatory rheology yenziwa kusetshenziswa i-controlled-stress rheometer ezingeni lokushisa lomzimba ukuze kunqunywe izakhiwo ze-viscoelastic ze-filler ngayinye, okuhlanganisa i-elastic modulus G', i-viscous modulus G'', kanye ne-phase angle δ, okuhlanganisa kuchaza ukuthi i-gel iphendula kanjani ekucindezelweni komzimba nasekuphazamisekeni ngesikhathi sokunyakaza kobuso. Lezi zilinganiso ze-rheological zibalulekile ekubikezeleni ukuthi i-filler izoziphatha kanjani ngaphansi kwezimo zamandla eziguquguqukayo zokubonakaliswa kobuso, amandla om

I-Scanning electron microscopy (SEM) yasetshenziswa ukubonisa i-microstructure yamasampula e-gel a-freeze-dried, yembula ukwakheka kwenethiwekhi ye-polymer e-crosslinked, ukusatshalaliswa kosayizi wezimbobo, kanye nokuba khona kwanoma yiziphi izinto eziyisiphalaphala noma ezifayibha ezingathinta ukuhlanganiswa kwezicubu kanye nokungena kwamaseli ngokuhamba kwesikhathi. Amasampula alungiswa kusetshenziswa inqubo ejwayelekile ye-freeze-drying ukulondoloza ukwakheka kwe-gel yasekuqaleni, futhi izithombe zathathwa ngezinga elihlukahlukene lokukhulisa ukuze kuhloliswe kokubili ukuhlelwa okukhulu kanye nemininingwane emihle ye-polymer matrix. I-Fourier-transform infrared spectroscopy (FTIR) yanikeza ukuqonda kwezinga lamakhemikhali ngokukhomba imibangela yokumunca eyaziwayo ye-hyaluronic acid kanye ne-crosslinking agent BDDE, iqinisekisa ubuqotho bamachemikhali bomkhiqizo futhi ivumela ukutholwa kwanoma yiziphi izinguquko zesakhiwo noma izinto ezingcolile ezingene ngesikhathi sokukhiqiza

Imiphumela yezifundo zokuchaza ibonisa umehluko ocacile futhi ofanele ngokwelashwa phakathi kweDermaxgel Deep, Dermaxgel Ultradeep, kanye nabalingani babo abancintisana nabo, ikakhulukazi ngokuya nge-elastic modulus G', isilinganiso sokuvuvukala, kanye nokuhlelwa kwe-microstructural njengoba kubonakala nge-SEM. I-Dermaxgel Ultradeep ibonise inani eliphakeme kakhulu le-G' phakathi kwazo zonke izampula ezihlolelwe, okubonisa ukuqina okungcono kakhulu kanye nekhono elihle kakhulu lokumelana nokuguquguquka ngaphansi kwemithwalo yokucindezela nokusika—impahla ehambisana ngqo namandla aqinile okuphakamisa lapho ijovwa ezindaweni ezijulile njengendwangu ye-supraperiosteal lapho kudingeka ukwesekwa kwamathambo. I-Dermaxgel Deep ibonise i-G' ephakathi nendawo ephakeme eyayibeka phakathi kwe-Ultradeep variant kanye nabagcwalisi abathambile abancintisana nabo, okuyenza ibe ukukhetha okuguquguqukayo kokubuyiselwa kwevolumu ye-midface kanye nokukhuliswa kwe-dermal ejulile lapho kudingeka khona ukulinganisela kokukhuphuka kanye nomuzwa wendwangu yemvelo ofunwa umsebenzisi kanye nesiguli. Ngokuphambene, imikhiqizo embalwa encintisana nayo enezinani eziphansi ze-G' ingase ifaneleke kakhulu kumjovo ongaphezulu noma izindawo eziguquguqukayo lapho ukuguquguquka kubaluleke kakhulu kunokwesekwa kwesakhiwo, kodwa ayinawo amandla aqinile okuphakamisa adingekayo ekukhulisweni kwamathambo noma ukulungisa ukushoda kwevolumu okucacile ebusweni obudala. Amanani e-G' emikhiqizo yeDermaxgel nawo ayebalulekile ngokungabi khona okuncane kokuhluka kwe-batch-to-batch, okuqinisa idumela lomkhiqizo lokungaguquguquki kokukhiqiza kanye nokulawula ikhwalithi okungathenjwa ngabasebenzisi ukuze bathole imiphumela ephindaphindekayo. Lokhu kungaguquguquki kubaluleke kakhulu esimweni sezokwelapha lapho kungasetshenziswa izitsha eziningi esikhathini esisodwa sesiguli, njengoba i-rheology efanayo iqinisekisa ukuthi ukwelashwa kuqhubeka ngendlela elindelekile kusukela ekuqaleni kuze kube sekupheleni.

Ukugcinwa kwamanzi, njengoba kulinganiswa ngesilinganiso sokuvuvukala esilinganiswe ku-phosphate-buffered saline ekushiseni komzimba, nakho kwahluka kakhulu phakathi kwezinto ezihlolwayo, lapho amafomula e-Dermaxgel ebonisa iphrofayili yokuvuvukala elinganiselayo egwema ukweqisa kokubili ukumanzi ngokweqile noma ukuhlanganiswa okunganele kwezicubu. I-Dermaxgel Deep ibonise isilinganiso sokuvuvukala esilinganiselayo esivumela ukulungiswa kwevolumu okusebenzayo ngaphandle kokubangela ukwanda okubonakalayo noma ukuvuvukala okuhlala njalo, okuyenza ilungele kakhulu izindawo ezifana nezingqimuzimu, imigqa ye-nasolabial, kanye ne-prejowl sulcus lapho kokubili ivolumu kanye nomumo wemvelo kubalulekile kumphumela ophumelelayo wobuhle. I-Dermaxgel Ultradeep, ngenkathi isagcina amandla okukhukhumala anengqondo, ibonise ukuthathwa kwamanzi okuncane kancane uma kuqhathaniswa ne-Deep, okuhambisana nenethiwekhi yayo eyenziwe ngokuqinile kanye ne-G' ephezulu—ukushintshana okubeka phambili ngenhloso ubuqotho besakhiwo kanye nokuphila isikhathi eside kunokwanda kwevolumu okubangelwa amanzi ngokushesha. I-Scanning electron microscopy ibonise ukuthi izinto zokugcwalisa ze-Dermaxgel zinokwakheka okufanayo, okuhlelekile okune-porous microstructure enokusabalalisa okufanayo kosayizi we-pore kuyo yonke i-gel matrix, okwenza kube lula ukungena kwamaseli, ukwakheka kwezicubu ezintsha, kanye nokuhlanganiswa okuyingxenye ne-host tissue emavikini alandela umjovo. Imikhiqizo yokuncintisana ngezinye izikhathi ibonise amanethiwekhi angalingani kakhulu anezikhala ezinkulu noma ezingalingani, okutholakele okungaholela ekuphenduleni okungalindelekile kwezicubu noma izindlela zokubola eziguquguqukayo eziyinkimbinkimbi umphumela wokwelashwa. Lezi zinzuzo ze-microstructural zemikhiqizo ye-Dermaxgel zigcizelela inani lezindlela ezithuthukisiwe zokuxhumanisa kanye nokwakheka ezibeka phambili kokubili ukusebenza komshini kanye nokuhambisana kwezinto eziphilayo ukuze kuqinisekiswe ukuphepha nokwaneliseka kwesiguli.

Umehluko wezakhiwo obonwe phakathi kweDermaxgel Deep, iDermaxgel Ultradeep, nemikhiqizo ebambisene nayo unemiphumela emikhulu ekusebenzeni kwezempilo, ikakhulukazi ngokuya ngamandla okukhuphula, ukuqina, kanye nomphumela wobuhle obuzwa isiguli kuyo yonke imijikelezo yokwelashwa. I-elastic modulus ephezulu i-G' iyavunywa kabanzi emibhalweni yezokwelapha esikhumbeni kanye nokuhlinzwa kobuhle njengesibikezeli esibaluleke kakhulu sokukwazi kwe-filler ukukhuphula nokusekela izicubu ezithambile ngokumelene namandla omfutho kanye namandla okubonisa ubuso, futhi i-G' ephakeme yeDermaxgel Ultradeep iyenza ibe ukukhetha okuhle kakhulu kwezinqubo ezidinga ukukhuliswa okunamandla kwezakhiwo. Lapho i-filler enokuqina okuphezulu ijovwa ujule ku-periosteum, yenza njengesakhiwo esiqinile esingakwazi ukuphakamisa kahle izicubu ezithambile ezihlezi phezu kwayo, ilungise ukuncipha kwamathambo okuhlobene nobudala kanye nokwehla kwezicubu ezithambile ngendlela imikhiqizo ye-G' ephansi engenakufeza ngayo noma ngabe ivolumu ejovwe ingakanani. Ngokuphambene, iDermaxgel Deep, enomklamo wayo omncane kodwa osabhekene kakhulu, inikeza isivumelwano esihle kakhulu ngeziguli ezidinga kokubili ukuphakama nokuzwakala okwemvelo, okuguquguqukayo lapho kuthintwa, okwenza ibe yisixazululo esihle kakhulu sokugcwalisa i-midface kanye nokulungiswa kwemigqa ye-nasolabial lapho i-filler kufanele izwakale ithambile kodwa futhi inikeze ukulungiswa okulinganisekayo. Isinqumo sezokwelapha phakathi kwalezi zinguqulo ezimbili ekugcineni sincike ekuqambeni okuyingqayizivele kwesiguli, ubujamo bokushoda kwezicubu, kanye nesilinganiso esifunwayo phakathi kokuphakama okusheshayo nokuhlanganiswa kwesikhathi eside. Odokotela abaqonda le mizwa ye-rheological bangalungiswa kangcono ukuba baxoxe neziguli ngendlela efanele mayelana nalokho umkhiqizo ngamunye ongakwenza futhi babeke izindaba ezifanele zomphumela wokwelashwa.

Ukuphila isinye isici esibalulekile sezokwelapha esithonywa ngqo izakhiwo zesakhiwo se-filler, ikakhulukazi ubuningi be-crosslinking, ukugxila kwe-hyaluronic acid, kanye nokumelana kwesigubhu ngokwemvelo nokubola kwe-enzymatic yi-hyaluronidase nokuhlaselwa yi-free radical endaweni yomjovo. I-Dermaxgel Ultradeep, enenethiwekhi yayo e-crosslinked eqinile kanye ne-G' ephezulu, ibonise ukuqina okwandisiwe ekusetshenzisweni kwezomtholile, ngokuvamile kuhlala izinyanga eziyi-12 kuye kweziyi-18 noma ngaphezulu kuncike endaweni yomjovo, umsebenzi we-metabolic wesiguli, kanye nevolumu yomkhiqizo obekwe esicini. Lokhu kuphila okwandisiwe kunciphisa ukuphindaphinda kokwelashwa okuthintwayo okudingekayo ukuze kugcinwe umphumela wobuhle oyifunayo, kuthuthukise ukwaneliseka kwesiguli nokusebenza kahle kwezindleko phakathi nohlelo lokwelashwa olungase luhlanganise iminyaka eminingana. I-Dermaxgel Deep iphinde inikeze ukuphila okuhle, ngokuvamile kusuka ezinyangeni eziyi-9 kuye kweziyi-15, okwenza kube ukukhetha okuthembekile kweziguli ezifuna imiphumela eqinile kodwa engalungiswa endaweni ephakathi kobuso nasemlonyeni lapho ukushintshwa kwemvelo kungase kube ngokushesha kancane. Isilinganiso sokuvuvukala naso sinomthelela ngqo ekuhlangenwe nako kwezomtholile: isivuvukalisi esimaphakathi njenge-Dermaxgel Deep sihlanganiswa kahle esicini ngaphandle kokubangela ukuvuvukala ngemuva komjovo noma ukubukeka okungaphezu kokulungiswa "komcamelo", okungaba yinto ekhathazayo ngama-fillers avuvukala kakhulu aqhubeka nokukhula ngemuva kokubekwa kwawo. Ngaphezu kwalokho, i-microstructure ye-homogeneous ebonwe yi-SEM emikhiqizweni ye-Dermaxgel isekela ukuhlanganiswa okulinganayo kwezicubu kanye ne-neovascularization, kunciphisa ubungozi bokwakheka kwe-nodule, ukuthuthukiswa kwe-granuloma, noma amaphethini okumunca angalingani angaphazamisa umphumela wobuhle futhi adinge ukulungiswa okuyilungisayo noma ukuncibilika komkhiqizo.

Uhlolojikelele olunzulu lwe-Dermaxgel Deep ne-Dermaxgel Ultradeep ngokusebenzisa ukuhlaziywa kwesilinganiso sokuvuvukala, i-oscillatory rheology, i-scanning electron microscopy, kanye ne-Fourier-transform infrared spectroscopy kunikeza uhlaka olucacile nolusebenzayo kubelaphi ukuba bakhethe i-filler efanelekayo kakhulu ezidingweni ezihlukile zomuntu ngamunye zesiguli kanye nezokubukeka. Idatha ibonisa ngokungangabazeki ukuthi i-Dermaxgel Ultradeep ilungiselelwe ukwengeza ivolumu enzulu, eyakhiwo edinga amandla aphezulu okukhuphula kanye nokuphila isikhathi eside, kanti i-Dermaxgel Deep inikeza inhlanganisela elinganisiwe yokuba lukhuni okumaphakathi, ukugcinwa kahle kwamanzi, kanye nokusetshenziswa okuguquguqukayo kwezempilo ezindaweni eziphakathi kobuso kanye nezindawo ezijulile zesikhumba. Ngokuqonda ukuthi ubuchwepheshe bokuxhumanisa, amapharamitha okwakheka, kanye nenhlangano encane yomkhiqizo kuguqulela ezicini ezilinganisekayo ze-rheological kanye nokuvuvukala, abasebenzi bangadlulela ngalé kokusetshenziswa okufanayo kuwo wonke umuntu futhi bamukele umkhuba wokubukeka oqhutshwa ngokunemba okuhambisana nezidingo ezithile zendawo ngayinye yokwelashwa kanye nephrofayela yesiguli. I-Dermaxgel, njengomkhiqizo osekelwa ubuchwepheshe namakhono okukhiqiza e-Merry, iyaqhubeka nokutshala imali ocwaningweni nasekuthuthukisweni ukuze kuthuthukiswe ngokuqhubekayo iqoqo layo le-filler, yandise isisekelo sayo sobufakazi bezokwelapha, futhi isekele izidingo eziguqukayo zomphakathi womhlaba wokubukeka ngezixazululo eziqhutshwa isayensi. Ukuzinikela kwenkampani kukhwalithi, ukwethembeka, kanye nemfundo kubeka yona njengomlingani omethembayo kubelaphi abafuna ukuletha izinga eliphezulu kakhulu lokunakekelwa kubantu abagula nabo besebenzisa imikhiqizo abangayithembela nsuku zonke.

Kubasebenzi abafuna ukujulisa ulwazi lwabo nge-hyaluronic acid dermal fillers futhi bahlale bephila ngokwazi okusha kwesayensi kanye nemikhiqizo emisha emkhakheni we-regenerative aesthetic medicine, siyakhuthaza ukuthi nihlole zonke izinsiza ezitholakala kuwebhusayithi yeDermaxgel. Noma ngabe nithanda imininingwane yezobuchwepheshe yobuchwepheshe bokuxhumanisa, idatha yomtholampilo ngemuva kweDermaxgel Deep kanye neUltradeep, noma isiqondiso esisebenzayo sokufaka le mikhiqizo emkhakheni wenu wansuku zonke,Ikhaya ikhasi futhi Mayelana Nathi ikhasi linikeza ukubuka konke okubanzi ngomsebenzi womkhiqizo, izitifiketi, nesisekelo sesayensi. Ngaphezu kwalokho, i-Imikhiqizo ikhasi lihlinzeka ngemininingwane enemininingwane nezinkomba zazo zonke izinhlobonhlobo ze-filler, kanti i-Izindaba ikhasi likugcina unolwazi mayelana nezifundo zakamuva, intuthuko yemakethe, namathuba emfundo emitholampilo yobuhle. nganoma yimiphi imibuzo noma ukucela ukwesekwa komtholampilo okwenziwe ngezifiso, i-Ukusekelwa leli khasi liyisango lakho losizo lochwepheshe nezincomo ezenziwe ngendlela ethize eqenjini leDermaxgel. Ngokuhlanganisa ukukhethwa komkhiqizo okusekelwe ubufakazi ngemfundo eqhubekayo nokuqeqeshwa okusebenzayo, abasebenzi bangandisa ukuphepha, ukusebenza kahle, nokwaneliseka okuhlotshaniswa nezihluthisi zeDermaxgel, ekugcineni bethule imiphumela emihle, ebukeka njengemvelo abayithokozelayo nabayikhumbulayo iziguli zabo.