I-Hyaluronic acid (HA) iyiglycosaminoglycan eyenzeka ngokwemvelo esabalalele kabanzi ezicini ezixhumanisa, ezihlanganisa, nezicubu zemizwa. Izici zayo ezihlukile zomzimba namakhemikhali, okuhlanganisa ukuhambisana kahle nomzimba nokukwazi okumangalisayo ukugcina amanzi, zimfakele phambili ocwaningweni lwezokwelapha nezicelo. I-HA idlala indima ebalulekile ekugcineni ukunisela kwezicubu, ukuqina, nokwakheka komzimba. Emihlathini yamuva nje, intshisekelo ekusetshenzisweni kwe-hyaluronic acid yenyukile, iqhutshwa yimidlalo yayo eminingi empilweni nasekwelapheni izifo. Lesi sihloko sihluza izicelo ezibanzi ze-HA, sigqamisa amandla ayo okuguqula ezindaweni ezahlukene zezokwelapha nezokuhlobisa.

Ubalulekile u-hyaluronic acid ngaphezu nje kokuba khona kwawo emzimbeni. Amandla awo okusebenzisana namaseli nokulawula imisebenzi yomzimba emenza abe yigugu kakhulu ezintweni ezithuthukisa imithi. Kusukela ekuthuthukiseni ukuphulukiswa kwamanxeba kuze kube ukusetshenziswa njengendlela yokulethwa kwemithi, ukusebenza kuka-HA akufani. Njengoba ubuchwepheshe be-biomedical buqhubeka, ukusetshenziswa kwezinto zokwakha zika-HA kuyashintsha, ngezindlela ezintsha ezifana nama-nanoparticles nama-hydrogels anikeza izixazululo ezintsha. Lesi sibuyekezo sibeka isiteji sokuhlola okuningiliziwe kwezici zika-HA ze-biomedical kanye nesikali sawo sezicelo.

I-Hyaluronic acid iyisithako esibalulekile se-extracellular matrix (ECM), lapho ihlinzeka ngendawo emanzi eyenza kube lula ukuhamba kwamaseli, ukwanda, nokuhlukana kwawo. Ifomu layo elinesisindo esikhulu lisiza ekubeni izicubu zibe ne-viscoelasticity futhi lisebenze njengamafutha, okubalulekile emalungeni nasemazinyweni. Ukusebenzisana kwe-HA nezamukeli ezisebusweni bamangqamuzana njenge-CD44 ne-RHAMM kuqalisa imifudlana yokuxwayisa ethinta ukuvuvukala, ukwakheka kwemithambo yegazi, nezinqubo zokulungisa amanxeba.

Ngaphezu kwalokho, ukubola kwe-HA nokungabikho kwayo kokubangela ukungasebenzi kahle komzimba kwenza kube yisicelo esihle kakhulu ezinhlelweni ezahlukahlukene zezokwelapha. Iphinde ibe nendima yokuvikela ngokwakha umgoqo ongokwemvelo ongavimbela izifo nokulawula izimpendulo zomzimba. Abacwaningi baqhubeka nokuthola ukubandakanyeka kwe-HA ekugcineni izindawo zamangqamuzana esithemba ukuthi azokhula (stem cell niches) kanye namandla ayo emitholampilo yokubuyisela izicubu. Ukuqonda lezi zici zezokwelapha kubalulekile ekuthuthukiseni imikhuba esekelwe ku-HA nasekuphakamiseni ukusebenza kwayo emtholampilo.

Ukusetshenziswa kwe-hyaluronic acid ekwakhiweni kwezicubu kufaka phakathi izisekelo ezilingisa i-ECM yemvelo, kukhuthaza ukulungiswa kwezicubu emalungeni, esikhunjeni, nasekulungisweni kwamathambo. Ukusetshenziswa kwayo ekwelapheni izilonda kubhalwe kahle, lapho izindwangu ezisekelwe ku-HA zikhawuleza ukulungiswa kwezicubu, zinciphise ukuphola, futhi zivimbele izifo ngokugcina indawo emanzi. Ekwelashweni komdlavuza, i-HA isetshenziselwa izinhlelo zokudiliva imithi ezihlosiwe ngenxa yokufana kwayo nama-receptor e-CD44, avame ukuba khona kakhulu kumagciwane omdlavuza, ngaleyo ndlela kuthuthukiswe ukukhetha kokwelapha futhi kuncishiswe ubuthi obujwayelekile.

Emitholweni yamehlo, i-HA iyisithako esibalulekile emاتhophini amehlo nasezinsizeni zokuhlinza, ihlanza futhi ivikela izindawo zamehlo. Izakhiwo zayo ze-viscoelastic zithuthukisa imiphumela yeziguli ekuhlinzweni kwamehlo acwebile nawemithambo. Imboni yezimonyo nayo yamukele i-hyaluronic acid ngemiphumela yayo yokunisela nokulwa nokuguga. Izinto zokugcwalisa ze-HA zibuyisela ivolumu yobuso futhi ziqinisa imibotshana, zinikeza enye indlela yokuhlinzwa engadingi ukuhlinzwa. Lezi zicelo ezahlukene zikhombisa ukusetshenziswa okubanzi kwe-HA nokubaluleka kwayo okukhulayo emikhakheni yezokwelapha neyobuhle.

Ukusungulwa kwakamuva ezintweni zokwakha ze-hyaluronic acid (HA) kudlule ukusetshenziswa kwayo okujwayelekile. Izendlalelo ze-HA ezintweni zokwelapha zithuthukisa ukuhambisana nomzimba futhi zinciphise ukunamathela kwamagciwane, ngaleyo ndlela kunciphise ubungozi bokutheleleka. Ama-nanoparticle enziwe nge-HA noma ahlanganiswe nge-HA asiza ukukhululwa kwezidakamizwa okulawulwayo kanye nokwelashwa okuhloswe, ikakhulukazi emikhakheni yomdlavuza nezifo ezivuvukalayo. Lawa ma-nanoparticle athuthukisa ukuzinza kwezidakamizwa kanye nokutholakala kwazo emzimbeni ngenkathi kuncishiswa imiphumela emibi.

Ama-hydrogel avela ku-HA enziwa ngobuchwepheshe ukuze alingise i-ECM yemvelo, anikele ngezici zemishini ezingashintshwa nezilinganiso zokubola ezihambisana nezicelo ezithile zezokwelapha njengokulungisa izicubu zomgogodla kanye nokugqoka amanxeba. La ma-hydrogel asekela ukufakwa kwamaseli nokukhula kwawo, okwenza abe nethemba ezindabeni zemithi yokubuyisela emzimbeni kanye nobuchwepheshe be-3D bioprinting. Izinkampani ezifana neDermax zisebenzisa ubuchwepheshe obusezingeni eliphezulu be-HA biomaterial ukuze zithuthukise imikhiqizo emisha yokwelapha neyokuzilungisa, zihlanganisa ucwaningo oluthuthukile namazinga aphezulu okukhiqiza. Ukuzibophezela kwabo ekuqanjweni okusha nasekuqhakazeleni kuqinisa umkhawulo wabo wokuncintisana emakethe yomhlaba wonke.

I-Hyaluronic acid iseyisisekelo esibalulekile ocwaningweni lwe-biomedical ngenxa yezici zayo ezihlukile nokusetshenziswa kwayo okubanzi. Izinkomba zesikhathi esizayo zihlanganisa ukuthuthukisa izinhlelo ezisekelwe ku-HA ezisebenza ngezindlela eziningi ezihlanganisa ukuxilonga kanye nemithi, ukuthuthukisa izindlela zemithi eyenziwe ngezifiso. Ukuthuthukiswa okuqhubekayo kwezinto ze-HA biomaterials kuzothuthukisa kakhulu ukusebenza kwazo kanye nemiphumela yeziguli emikhakheni ehlukahlukene yezokwelapha. Ubuchwepheshe obusakhula njenge-nanomedicine kanye ne-biofabrication banethemba lokwandisa indima ye-HA emikhakheni yokwelapha yesizukulwane esilandelayo.

I-Dermax, ngendlela yayo entsha kanye nobuchwepheshe kwezobuchwepheshe bezokwelapha, idlala indima ebalulekile ekushayeleni lezi zintuthuko. Ngokuhlanganisa izinto ezisezingeni eliphezulu ze-HA biomaterials ezintweni abazinikezayo, banikela ekuguquleni izindlela zokwelapha nasekuphuculeni izinga lempilo. Ngeminye imininingwane ngemikhiqizo yabo neziqalo zabo, vakashela ikhasi le-"Products", noma ufunde kabanzi ngomsebenzi wenkampani nobuchwepheshe babo ekhasini le-"About Us",Imikhiqizo ikhasi, noma ufunde kabanzi ngomsebenzi wenkampani nobuchwepheshe babo ekhasini le-Mayelana Nathi isigaba.